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Article

IRAK1 functional genetic variant affects severity of septic shock.

Critical care medicine - 1 Dec 2010

Toubiana Julie, Courtine Emilie, Pène Frédéric, Viallon Vivian, Asfar Pierre, Daubin Cédric, Rousseau Christophe, Chenot Claire, Ouaaz Fatah, Grimaldi David, Cariou Alain, Chiche Jean-Daniel, Mira Jean-Paul

Abstract excerpt

OBJECTIVES: Excessive inflammation is closely related to severity and outcome of sepsis. Because interleukin-1-receptor-associated kinase 1 is a key signaling protein in the activation of NF-κB during infection, we aimed to evaluate the effect of functionally relevant haplotypes of IRAK1 on severity, development of acute lung injury, and mortality in septic shock. DESIGN: Prospective, observational, cohort study....

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Source

Identifiers

PMID: 20890200
DOI: 10.1097/CCM.0b013e3181f9f9c7

Genes

IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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