Article
Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients.
Shock (Augusta, Ga.) - 1 Dec 2015
Ramakers Bart P, Giamarellos-Bourboulis Evangelos J, Tasioudis Chronis, Coenen Marieke J H, Kox Matthijs, Vermeulen Sita H, Groothuismink Johanne M, van der Hoeven Johannes G, Routsi Christina, Savva Athina, Prekates Athanassios, Diamantea Filia, Sinapidis Dimitrios, Smits Paul, Toutouzas Konstantinos, Riksen Niels P, Pickkers Peter
Abstract excerpt
INTRODUCTION: Adenosine exerts anti-inflammatory and tissue-protective effects during systemic inflammation. While the tissue-protective effects might limit organ damage, its anti-inflammatory properties may induce immunoparalysis and impede bacterial clearance. The common 34C>T loss-of-function variant of AMPD1 (rs17602729) is associated with increased adenosine formation, but effects on immune function and...
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