Article
The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.
Innate immunity - 1 Jul 2021
Hugo Montes A, Valle-Garay Eulalia, Martin Guadalupe, Collazos Julio, Alvarez Victoria, Meana Alvaro, Pérez-Is Laura, Carton José A, Taboada Francisco, Asensi Víctor
Abstract excerpt
Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine genes might modify their transcription or expression, plasma cytokines levels and response to sepsis. Activation protein-1 (AP-1) and NF-κB regulate cytokines gene expression in sepsis. A total of 90 severely septic and 91 non-infected patients were prospectively studied. IL-1α (-889 C/T),...
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