Article
The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.
Anesthesiology - 1 Jan 2013
Adamzik Michael, Schäfer Simon, Frey Ulrich H, Becker Arne, Kreuzer Maximiliane, Winning Sandra, Frede Stilla, Steinmann Jörg, Fandrey Joachim, Zacharowski Kai, Siffert Winfried, Peters Jürgen, Hartmann Matthias
Abstract excerpt
BACKGROUND: Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after lipopolysaccharide stimulation; (2) affects lipopolysaccharide-induced NF-κB1 messenger RNA...
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