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Article

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.

Mechanisms of ageing and development - 1 Jan 2000

Akbari Mansour, Krokan Hans E

Abstract excerpt

Endogenous factors constitute a substantial source of damage to the genomic DNA. The type of damage includes a number of different base lesions and single- and double-strand breaks. Unrepaired DNA damage can give rise to mutations and may cause cell death. A number of studies have demonstrated an association between aging and the accumulation of DNA damage. This may be attributed to reduced DNA repair with age,...

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Identifiers

PMID: 18355895
DOI: 10.1016/j.mad.2008.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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