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Article

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.

Biological psychiatry - 15 Mar 2023

Kember Rachel L, Hartwell Emily E, Xu Heng, Rotenberg James, Almasy Laura, Zhou Hang, Gelernter Joel, Kranzler Henry R

Abstract excerpt

BACKGROUND: Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRSs) and phenome-wide association studies are useful in evaluating pleiotropic effects. However, the comparatively low prevalence of SUDs in population samples and the lack of detailed information available in electronic...

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Identifiers

PMID: 36273948
DOI: 10.1016/j.biopsych.2022.08.010
PMCID: PMC9931661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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