Article
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
Nature neuroscience - 1 Jul 2020
Zhou Hang, Sealock Julia M, Sanchez-Roige Sandra, Clarke Toni-Kim, Levey Daniel F, Cheng Zhongshan, Li Boyang, Polimanti Renato, Kember Rachel L, Smith Rachel Vickers, Thygesen Johan H, Morgan Marsha Y, Atkinson Stephen R, Thursz Mark R, Nyegaard Mette, Mattheisen Manuel, Børglum Anders D, Johnson Emma C, Justice Amy C, Palmer Abraham A, McQuillin Andrew, Davis Lea K, Edenberg Howard J, Agrawal Arpana, Kranzler Henry R, Gelernter Joel
Abstract excerpt
Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU, combining alcohol use disorder and problematic drinking, in 435,563 European-ancestry individuals. We identified 29 independent risk variants,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.