Article
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.
Nature genetics - 1 Dec 2023
Levey Daniel F, Galimberti Marco, Deak Joseph D, Wendt Frank R, Bhattacharya Arjun, Koller Dora, Harrington Kelly M, Quaden Rachel, Johnson Emma C, Gupta Priya, Biradar Mahantesh, Lam Max, Cooke Megan, Rajagopal Veera M, Empke Stefany L L, Zhou Hang, Nunez Yaira Z, Kranzler Henry R, Edenberg Howard J, Agrawal Arpana, Smoller Jordan W, Lencz Todd, Hougaard David M, Børglum Anders D, Demontis Ditte, Gaziano J Michael, Gandal Michael J, Polimanti Renato, Stein Murray B, Gelernter Joel
Abstract excerpt
As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities. Here we performed a genome-wide association study of CanUD in the Million Veteran Program (MVP), followed by meta-analysis in 1,054,365 individuals (ncases = 64,314) from four...
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