Article

Gene regulatory network of human GM-CSF secreting T helper cells

2019-02-20

Abstract excerpt

<h4>ABSTRACT</h4> GM-CSF produced by autoreactive CD4 positive T helper cells is involved in the pathogenesis of autoimmune diseases, such as Multiple Sclerosis. However, the molecular regulators that establish and maintain the features of GM-CSF positive CD4 T cells are unknown. In order to identify these regulators, we isolated human GM-CSF producing CD4 T cells from human peripheral blood by using a cytokine c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 388d2d81-a98f-505f-a5b8-e9c5aaf0621d
DOI: 10.1101/555433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene regulatory network of human GM-CSF secreting T helper cellsDOI 10.1101/555433Read

A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple SclerosisSemantic proximity Read

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases.Semantic proximity Read

Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype.Semantic proximity Read

Comprehensive mapping of the human cytokine gene regulatory networkSemantic proximity Read

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosisSemantic proximity Read

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritisSemantic proximity Read

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cellsSemantic proximity Read

Three-dimensional genome structure and chromatin accessibility reorganization during <i>in vivo</i> induction of human T cell toleranceSemantic proximity Read

Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB ProteinsSemantic proximity Read

Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cellsSemantic proximity Read

The promoter regions of intellectual disability-associated genes are uniquely enriched in LTR sequences of the MER41 primate-specific endogenous retrovirus: an evolutionary connection between immunity and cognitionSemantic proximity Read

Glia Maturation Factor Gamma (GMFG): A Cytokine-Responsive Protein During Hematopoietic Lineage Development and Its Functional Genomics AnalysisSemantic proximity Read