Article

Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS Autoimmunity

2023-12-25

Abstract excerpt

Pathogenic Th17 cells play crucial roles in CNS autoimmune diseases such as multiple sclerosis (MS), but their regulation by endogenous mechanisms remains unknown. Through RNA-seq analysis of primary brain glial cells, we identified immuno-responsive gene 1 ( Irg1 ) as one of the highly upregulated gene under inflammatory conditions. Validation in the spinal cord of animals with experimental autoimmune encephalom...

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Literature Corpus work: 7be57a27-66e2-5a20-a072-25301f9dd29b
DOI: 10.1101/2023.12.24.573264

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