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Article

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

Nature communications - 3 Oct 2014

Hartmann Felix J, Khademi Mohsen, Aram Jehan, Ammann Sandra, Kockum Ingrid, Constantinescu Cris, Gran Bruno, Piehl Fredrik, Olsson Tomas, Codarri Laura, Becher Burkhard

Abstract excerpt

Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell differentiation are associated with risk of developing MS. However, the underlying mechanism by which these risk alleles influence MS susceptibility has remained elusive. Initiation of neuroinflammation in animal models of...

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PMID: 25278028
DOI: 10.1038/ncomms6056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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