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Article

TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells.

Glia - 1 Nov 2016

Parsa Roham, Lund Harald, Tosevski Ivana, Zhang Xing-Mei, Malipiero Ursula, Beckervordersandforth Jan, Merkler Doron, Prinz Marco, Gyllenberg Alexandra, James Tojo, Warnecke Andreas, Hillert Jan, Alfredsson Lars, Kockum Ingrid, Olsson Tomas, Fontana Adriano, Suter Tobias, Harris Robert A

Abstract excerpt

Intracerebral levels of Transforming Growth Factor beta (TGFβ) rise rapidly during the onset of experimental autoimmune encephalomyelitis (EAE), a mouse model of Multiple Sclerosis (MS). We addressed the role of TGFβ responsiveness in EAE by targeting the TGFβ receptor in myeloid cells, determining that Tgfbr2 was specifically targeted in monocyte-derived dendritic cells (moDCs) but not in CNS resident microglia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27479807
DOI: 10.1002/glia.23033
PMCID: PMC5053226

Genes

CYBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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