Article

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells

2024-01-27

Abstract excerpt

<h4>SUMMARY</h4> Regulatory T (T reg ) cells are critical for maintaining peripheral tolerance and preventing autoimmunity. T reg cell depletion or dysfunction rapidly results in fatal multiorgan inflammation linked to unrestrained effector T cell expansion, but the cytokine network underlying immunopathology, and its direct cellular mediators, remain elusive. Here, we combined gene targeting, fate-mapping tool...

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Literature Corpus work: ecd30aba-99b5-5599-866a-a0029e2d0bed
DOI: 10.1101/2024.01.24.577048

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