ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

Abstract excerpt

Inappropriate CD4 + T helper (Th) differentiation can compromise host immunity or promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we examined mutations that modify risk for multiple sclerosis (MS), a canonical organ-specific autoimmune disease. This analysis identified a role for Zinc finger E-box-binding homeobox (ZEB1). Deletion of ZEB1 protects against experimental...

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