Article
Therapy-related clonal cytopenia as a precursor to therapy-related myeloid neoplasms.
Blood cancer journal - 8 Jul 2022
Shah Mithun Vinod, Mangaonkar Abhishek A, Begna Kebede H, Alkhateeb Hassan B, Greipp Patricia, Nanaa Ahmad, Elliott Michelle A, Hogan William J, Litzow Mark R, McCullough Kristen, Tefferi Ayalew, Gangat Naseema, Patnaik Mrinal M, Al-Kali Aref, He Rong, Chen Dong
Abstract excerpt
Therapy-related myeloid neoplasms (t-MN) are aggressive leukemia that develops as a complication of prior exposure to DNA-damaging agents. Clonal cytopenia of undetermined significance (CCUS) is a precursor of de novo myeloid neoplasms. Characteristics of CCUS that develop following cytotoxic therapies (therapy-related clonal cytopenia, t-CC) and outcomes following t-CC have not been described. We identified 33...
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