Article
Predicting cytopenias, progression, and survival in patients with clonal cytopenia of undetermined significance: a prospective cohort study.
The Lancet. Haematology - 1 Jan 2024
Cargo Catherine, Bernard Elsa, Beinortas Tumas, Bolton Kelly L, Glover Paul, Warren Helen, Payne Daniel, Ali Rukhsaar, Khan Alesia, Short Mike, Van Hoppe Suzan, Smith Alex, Taylor Jan, Evans Paul, Papaemmanuil Elli, Crouch Simon
Abstract excerpt
BACKGROUND: Somatic mutations are frequently reported in individuals with cytopenia but without a confirmed haematological diagnosis (clonal cytopenia of undetermined significance; CCUS). These patients have an increased risk of progression to a myeloid malignancy and worse overall survival than those with no such mutations. To date, studies have been limited by retrospective analysis or small patient numbers. We...
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