Article
The impact of cytotoxic therapy on the risk of progression and death in clonal cytopenia(s) of undetermined significance.
Blood advances - 25 Jun 2024
Li Marissa, Baranwal Anmol, Gurney Mark, Shah Syed N, Al-Kali Aref, Alkhateeb Hassan, Foran James, Arana Yi Cecilia, Ongie Laura, Chen Dong, Mangaonkar Abhishek, McCullough Kristen, Tefferi Ayalew, Lasho Terra, Finke Christy, Patnaik Mrinal M, Shah Mithun Vinod
Abstract excerpt
ABSTRACT: Clonal cytopenia of undetermined significance (CCUS) is defined by a myeloid driver mutation in the context of otherwise unexplained cytopenia. CCUS has an inherent risk of progressing to myeloid neoplasm. However, it is unknown how exposure to previous cytotoxic therapy may impact the risk of progression and survival. We stratified patients with CCUS by prior exposure to DNA-damaging therapy. Of 151...
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