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Article

Clinical implications and genetic features of clonal cytopenia of undetermined significance compared to lower-risk myelodysplastic syndrome.

British journal of haematology - 1 Aug 2022

Choi Eun-Ji, Cho Young-Uk, Hur Eun-Hye, Park Han-Seung, Choi Yunsuk, Lee Jung-Hee, Lee Kyoo-Hyung, Kim Miyoung, Hwang Sang-Hyun, Jang Seongsoo, Park Chan-Jeoung, Seo Eul-Ju, Lee Je-Hwan

Abstract excerpt

Clonal cytopenia of undetermined significance (CCUS) is characterized by persistent cytopenias with genetic aberrations, which do not meet the diagnostic criteria for myelodysplastic syndrome (MDS). We aimed to compare the clinical and genetic characteristics of CCUS with lower-risk MDS and identify patients with CCUS with a high risk of progression. We performed targeted sequencing of bone marrow (BM) samples...

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PMID: 35612271
DOI: 10.1111/bjh.18273

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