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Neuron‐specific translational control shift ensures proteostatic resilience during ER stress

6 Jul 2022

Abstract excerpt

Proteostasis is essential for cellular survival and particularly important for highly specialised post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase R‐like endoplasmic reticulum (ER) kinase (PERK)‐mediated phosphorylation of eukaryotic translation initiation factor 2α (p‐eIF2α) is a major proteostatic survival response during ER stress. Paradoxically, neurons are...

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PMID: 35791631
DOI: 10.15252/embj.2021110501

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