Article

The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

2020-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Large cytosolic protein aggregates are removed by two main cellular processes, autophagy and the ubiquitin-proteasome system (UPS), and defective clearance of these protein aggregates results in proteotoxicity and cell death. Here we show that the eIF2α kinase HRI potentiates the autophagic clearance of cytosolic protein aggregates when the UPS is inhibited. In cells silenced for HRI, proteasome...

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Literature Corpus work: fc5f7f54-7dcf-5c32-b4ef-be04525622ff
DOI: 10.1101/2020.05.12.092072

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