Article

eIF2B localisation and its regulation during the integrated stress response is cell type specific

2023-01-10

Abstract excerpt

Eukaryotic initiation factor 2B (eIF2B) is a master regulator of translation control. eIF2B recycles inactive eIF2-GDP to active eIF2-GTP. Under transient/acute cellular stress, a family of kinases phosphorylate the alpha subunit of eIF2 (eIF2α-P[S51]) activating the integrated stress response (ISR). This response pathway inhibits eIF2B activity resulting in overall translation attenuation and reprogramming of gen...

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Literature Corpus work: 174e69c8-eed2-5bd2-b74c-02e8a46ef760
DOI: 10.1101/2023.01.10.523470

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