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Article

Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis.

Cell death & disease - 26 May 2020

Bugallo Ricardo, Marlin Elías, Baltanás Ana, Toledo Estefanía, Ferrero Roberto, Vinueza-Gavilanes Rodrigo, Larrea Laura, Arrasate Montserrat, Aragón Tomás

Abstract excerpt

Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises a set of signaling mechanisms that initiate a gene expression program to restore proteostasis, or when stress is chronic or overwhelming promote neuronal death. This fate-defining capacity of...

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PMID: 32457286
DOI: 10.1038/s41419-020-2601-2
PMCID: PMC7250913

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