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Rational Design of ssODN to Correct Mutations by Gene Editing.

Biochemistry. Biokhimiia - 1 May 2022

Volodina Olga V, Anuchina Arina A, Zainitdinova Milyausha I, Evtushenko Nadezhda A, Lavrov Alexander V, Smirnikhina Svetlana A

Abstract excerpt

Gene editing allows to make a variety of targeted changes in genome, which can potentially be used to treat hereditary human diseases. Despite numerous studies in this area, effectiveness of gene editing methods for correcting mutations is still low, so these methods are not allowed in routine practice. It has been shown that rational design of genome editing components can significantly increase efficiency of...

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PMID: 35790380
DOI: 10.1134/S0006297922050078

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