Article

Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells

2024-06-07

Abstract excerpt

<title>Abstract</title> <p>Single-stranded oligodeoxyribonucleotide (ssODN) gene editing has emerged as a promising therapeutic strategy. However, further improvements in efficiency are desired for practical application. The effects of strand length and locked nucleic acid (LNA) modification on ssODN genome editing were investigated by introducing an assay cassette into the genome of HEK293T cells and measuring p...

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Literature Corpus work: 2bada008-0aa1-53ad-ab8d-7103233fa29f
DOI: 10.21203/rs.3.rs-4463420/v1

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