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Article

SparseSignatures: An R package using LASSO-regularized non-negative matrix factorization to identify mutational signatures from human tumor samples.

STAR protocols - 16 Sept 2022

Mella Lorenzo, Lal Avantika, Angaroni Fabrizio, Maspero Davide, Piazza Rocco, Sidow Arend, Antoniotti Marco, Graudenzi Alex, Ramazzotti Daniele

Abstract excerpt

We outline the features of the R package SparseSignatures and its application to determine the signatures contributing to mutation profiles of tumor samples. We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analysis, (2) determine the optimal parameters, and (3) employ them to determine the signatures and related exposure levels in the point mutation...

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Identifiers

PMID: 35779264
DOI: 10.1016/j.xpro.2022.101513
PMCID: PMC9256827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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