Article

De Novo Mutational Signature Discovery in Tumor Genomes using SparseSignatures

2018-08-04

Abstract excerpt

Cancer is the result of mutagenic processes that can be inferred from tumor genomes by analyzing rate spectra of point mutations, or “mutational signatures”. Here we present SparseSignatures, a novel framework to extract signatures from somatic point mutation data. Our approach incorporates a user-specified background signature, employs regularization to reduce noise in non-background signatures, uses cross-valida...

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Literature Corpus work: 488862fd-94a2-5748-b442-88cd41fc7197
DOI: 10.1101/384834

Open publication

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