Article
Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.
Bioinformatics (Oxford, England) - 1 Dec 2023
Díaz-Gay Marcos, Vangara Raviteja, Barnes Mark, Wang Xi, Islam S M Ashiqul, Vermes Ian, Duke Stephen, Narasimman Nithish Bharadhwaj, Yang Ting, Jiang Zichen, Moody Sarah, Senkin Sergey, Brennan Paul, Stratton Michael R, Alexandrov Ludmil B
Abstract excerpt
MOTIVATION: Analysis of mutational signatures is a powerful approach for understanding the mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the mutational signatures operative in a cancer genome, one first needs to quantify their activities by estimating the number of mutations imprinted by each signature. RESULTS: Here we present SigProfilerAssignment, a desktop and an online...
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