Article

Decomposition of mutational context signatures using quadratic programming methods

2016-06-07

Abstract excerpt

<h4>Methods: </h4> for inferring signatures of mutational contexts from large cancer sequencing data sets are invaluable for biological research, but impractical for clinical application where we require tools that decompose the context data for an individual into signatures. One such method has recently been published using an iterative linear modelling approach. A natural alternative places the problem within a...

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Literature Corpus work: a9b2ac69-cef4-5213-8d39-c025e4e0bb6d
DOI: 10.12688/f1000research.8918.1

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