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Article

Deep Unfolding for Non-Negative Matrix Factorization with Application to Mutational Signature Analysis.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2022

Nasser Rami, Eldar Yonina C, Sharan Roded

Abstract excerpt

Non-negative matrix factorization (NMF) is a fundamental matrix decomposition technique that is used primarily for dimensionality reduction and is increasing in popularity in the biological domain. Although finding a unique NMF is generally not possible, there are various iterative algorithms for NMF optimization that converge to locally optimal solutions. Such techniques can also serve as a starting point for...

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Identifiers

PMID: 34986029
DOI: 10.1089/cmb.2021.0438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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