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Article

Exosomal Transfer of DNA Methyl-Transferase mRNA Induces an Immunosuppressive Phenotype in Human Monocytes.

Shock (Augusta, Ga.) - 1 Jun 2022

Wisler Jon R, Singh Kanhaiya, McCarty Adara, Harkless Ryan, Karpurapu Manjula, Hernandez Edward, Mukherjee Debasmita, Abouhashem Ahmed S, Christman John W, Sen Chandan K

Abstract excerpt

INTRODUCTION: Survivors of sepsis exhibit persistent immunosuppression. Epigenetic events may be responsible for some of these immunosuppressive changes. During sepsis circulating exosomes contain large quantities of DNA methyltransferase (DNMT) mRNAs. We hypothesized that exosomes directly transfer DNMT mRNAs to recipient monocytes with resultant methylation events and immunosuppression. METHODS: Exosomes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35759303
DOI: 10.1097/SHK.0000000000001928
PMCID: PMC9420543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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