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Article

Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes

18 Feb 2022

Abstract excerpt

BACKGROUND: The maternal immune system needs to tolerate the semi-allogeneic fetus in pregnancy. The adaptation occurs locally at the maternal-fetal interface as well as systemically through the maternal circulation. Failure to tolerate the paternal antigens may result in pregnancy complications, such as pregnancy loss and pre-eclampsia. However, the mechanism that regulates maternal immune tolerance, especially...

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PMID: 35180876
DOI: 10.1186/s12951-022-01283-2

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