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Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes

21 Dec 2018

Abstract excerpt

Background: Bone marrow mesenchymal stem cells (bmMSC) may play a role in the regulation of maturation, proliferation and functional activation of lymphocytes, though the exact mechanisms are unknown. MSC-derived exosomes induce a regulatory response in the function of B, T and monocyte-derived dendritic cells. Here we evaluated the specific inhibition of human lymphocytes by bmMSC-derived exosomes and the...

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PMID: 30622539
DOI: 10.3389/fimmu.2018.03053

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