Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adult Rats With a Human Polymorphism (rs2304297) in the 3'-Untranslated Region of the CHRNA6 Gene.

doi:10.1093/ntr/ntaf147

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Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adult Rats With a Human Polymorphism (rs2304297) in the 3'-Untranslated Region of the CHRNA6 Gene.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 24 Feb 2026

Castro Emily M, Nguyen Michelle T, Georgy David Hany, Lotfipour Shahrdad

Abstract excerpt

INTRODUCTION: The widespread use of nicotine across ages culminates in substantial consequences on individual health, public health, and broader socioeconomic strain. Concerningly, adolescence is a uniquely vulnerable stage in which exploratory drug exposure imposes detrimental effects on reward circuitry, cognitive function, and neurochemical processes. A single nucleotide polymorphism (SNP), rs2304297, in the...

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PMID: 40736212
DOI: 10.1093/ntr/ntaf147

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CHRNA6

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