Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3'-UTR of the CHRNA6 Gene.

International journal of molecular sciences - 15 Mar 2022

Cardenas Anjelica, Bai Yu, Hajy Heydary Yasamin, Li Jiaqi, Leslie Frances M, Lotfipour Shahrdad

Abstract excerpt

In human adolescents, a single nucleotide polymorphism (SNP), rs2304297, in the 3'-UTR of the nicotinic receptor subunit gene, CHRNA6, has been associated with increased smoking. To study the effects of the human CHRNA6 3'-UTR SNP, our lab generated knock-in rodent lines with either C or G SNP alleles. The objective of this study was to determine if the CHRNA6 3'-UTR SNP is functional in the knock-in rat lines....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adolescent

Share to Genotype

Share to Nicotine

Share to Polymorphism, Single Nucleotide

Share to Receptors, Nicotinic

Source

Open in PubMed Open full text

Identifiers

PMID: 35328565
DOI: 10.3390/ijms23063145
PMCID: PMC8948824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3'-UTR of the CHRNA6 Gene.PMID 35328565Read ↗

Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adult Rats With a Human Polymorphism (rs2304297) in the 3'-Untranslated Region of the CHRNA6 Gene.Semantic proximity Read ↗

Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the Human CHRNA6 3'-UTR Single-Nucleotide Polymorphism (rs2304297) in Rats.Semantic proximity Read ↗

Mutation of the α5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption.Semantic proximity Read ↗

A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic RatsSemantic proximity Read ↗

From men to mice: CHRNA5/CHRNA3, smoking behavior and disease.Semantic proximity Read ↗

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.Semantic proximity Read ↗

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.Semantic proximity Read ↗

Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment.Semantic proximity Read ↗

Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.Semantic proximity Read ↗

Nicotine consumption is regulated by a human polymorphism in dopamine neurons.Semantic proximity Read ↗

The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice.Semantic proximity Read ↗

Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.