Article

Gain-of-function, focal segmental glomerulosclerosis <i>Trpc6</i> mutation minimally affects susceptibility to renal injury in several mouse models

2022-02-13

Abstract excerpt

Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans. Many of these mutations are known to have a gain-of-function effect on the non-specific cation channel function of TRPC6. In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely compared wild-type and Trpc6 -deficient rodents. We developed mice carrying...

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Literature Corpus work: c8574a49-ff15-50d8-8589-187835dcc1f1
DOI: 10.1101/2022.02.11.479954

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