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Article

Recent advances in targeting LRRK2 for Parkinson's disease treatment.

Journal of translational medicine - 8 Jul 2025

Karami Mahsa, Sanaye Pantea Majma, Ghorbani Atousa, Amirian Roshanak, Goleij Pouya, Babamohamadi Mehregan, Izadi Zhila

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approaches, necessitating exploring alternative methods anchored on genetic factors, notably the leucine-rich repeat kinase 2...

Topics

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Humans
Parkinson Disease
Molecular Targeted Therapy
Animals
Mutation
Clinical Trials as Topic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40629324
DOI: 10.1186/s12967-025-06354-0
PMCID: PMC12235878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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