TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

doi:10.1200/JCO.2017.75.5215

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Article

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2018

Qian Maoxiang, Cao Xueyuan, Devidas Meenakshi, Yang Wenjian, Cheng Cheng, Dai Yunfeng, Carroll Andrew, Heerema Nyla A, Zhang Hui, Moriyama Takaya, Gastier-Foster Julie M, Xu Heng, Raetz Elizabeth, Larsen Eric, Winick Naomi, Bowman W Paul, Martin Paul L, Mardis Elaine R, Fulton Robert, Zambetti Gerard, Borowitz Michael, Wood Brent, Nichols Kim E, Carroll William L, Pui Ching-Hon, Mullighan Charles G, Evans William E, Hunger Stephen P, Relling Mary V, Loh Mignon L, Yang Jun J

Abstract excerpt

Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fraumeni syndrome; however, the pattern, prevalence, and clinical relevance of TP53 variants in childhood ALL remain...

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Identifiers

PMID: 29300620
DOI: 10.1200/JCO.2017.75.5215
PMCID: PMC5815403

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