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Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth

23 Jun 2022

Abstract excerpt

Myofibrils of the skeletal muscle are comprised of sarcomeres that generate force by contraction when myosin-rich thick filaments slide past actin-based thin filaments. Surprisingly little is known about the molecular processes that guide sarcomere assembly in vivo, despite deficits within this process being a major cause of human disease. To overcome this knowledge gap, we undertook a forward genetic screen...

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PMID: 35737712
DOI: 10.1371/journal.pgen.1010287

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