Article
Understanding cardiac sarcomere assembly with zebrafish genetics.
Anatomical record (Hoboken, N.J. : 2007) - 1 Sept 2014
Yang Jingchun, Shih Yu-Huan, Xu Xiaolei
Abstract excerpt
Mutations in sarcomere genes have been found in many inheritable human diseases, including hypertrophic cardiomyopathy. Elucidating the molecular mechanisms of sarcomere assembly shall facilitate understanding of the pathogenesis of sarcomere-based cardiac disease. Recently, biochemical and genomic studies have identified many new genes encoding proteins that localize to the sarcomere. However, their precise...
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