Article
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.
Development (Cambridge, England) - 1 Mar 2008
Hawkins Thomas A, Haramis Anna-Pavlina, Etard Christelle, Prodromou Chrisostomos, Vaughan Cara K, Ashworth Rachel, Ray Saikat, Behra Martine, Holder Nigel, Talbot William S, Pearl Laurence H, Strähle Uwe, Wilson Stephen W
Abstract excerpt
The mechanisms that regulate sarcomere assembly during myofibril formation are poorly understood. In this study, we characterise the zebrafish sloth(u45) mutant, in which the initial steps in sarcomere assembly take place, but thick filaments are absent and filamentous I-Z-I brushes fail to align or adopt correct spacing. The mutation only affects skeletal muscle and mutant embryos show no other obvious...
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