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Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in <i>Drosophila</i> flight muscle

2023-06-26

Abstract excerpt

Muscles undergo developmental transitions in gene expression and alternative splicing that are necessary to refine sarcomere structure and contractility. CUG-BP and ETR-3-like (CELF) family RNA binding proteins are important regulators of RNA processing during myogenesis that are misregulated in diseases such as myotonic dystrophy (DM1). Here we report a conserved function for Bruno 1 (Bru1, Arrest), a CELF1/2 fam...

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Literature Corpus work
d12d6a21-4117-5b73-a9d4-9cb5a9e396bf
DOI
10.1101/2023.06.24.546382
Open publication

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Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in <i>Drosophila</i> flight muscleDOI 10.1101/2023.06.24.546382
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