Article
The myosin-interacting protein SMYD1 is essential for sarcomere organization.
Journal of cell science - 15 Sept 2011
Just Steffen, Meder Benjamin, Berger Ina M, Etard Christelle, Trano Nicole, Patzel Eva, Hassel David, Marquart Sabine, Dahme Tillman, Vogel Britta, Fishman Mark C, Katus Hugo A, Strähle Uwe, Rottbauer Wolfgang
Abstract excerpt
Assembly, maintenance and renewal of sarcomeres require highly organized and balanced folding, transport, modification and degradation of sarcomeric proteins. However, the molecules that mediate these processes are largely unknown. Here, we isolated the zebrafish mutant flatline (fla), which shows disturbed sarcomere assembly exclusively in heart and fast-twitch skeletal muscle. By positional cloning we...
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