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Article

Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells.

Circulation - 20 Sept 2022

Solomon Charles U, McVey David G, Andreadi Catherine, Gong Peng, Turner Lenka, Stanczyk Paulina J, Khemiri Sonja, Chamberlain Julie C, Yang Wei, Webb Tom R, Nelson Christopher P, Samani Nilesh J, Ye Shu

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progress to medical translation. Evidence suggests that the genetic influence on CAD susceptibility may act partly through vascular smooth muscle cells (VSMCs). METHODS:...

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Share to Coronary Artery Disease
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 35735005
DOI: 10.1161/CIRCULATIONAHA.121.058389
PMCID: PMC9484647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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