Article
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.
Nature medicine - 1 Aug 2022
Tcheandjieu Catherine, Zhu Xiang, Hilliard Austin T, Clarke Shoa L, Napolioni Valerio, Ma Shining, Lee Kyung Min, Fang Huaying, Chen Fei, Lu Yingchang, Tsao Noah L, Raghavan Sridharan, Koyama Satoshi, Gorman Bryan R, Vujkovic Marijana, Klarin Derek, Levin Michael G, Sinnott-Armstrong Nasa, Wojcik Genevieve L, Plomondon Mary E, Maddox Thomas M, Waldo Stephen W, Bick Alexander G, Pyarajan Saiju, Huang Jie, Song Rebecca, Ho Yuk-Lam, Buyske Steven, Kooperberg Charles, Haessler Jeffrey, Loos Ruth J F, Do Ron, Verbanck Marie, Chaudhary Kumardeep, North Kari E, Avery Christy L, Graff Mariaelisa, Haiman Christopher A, Le Marchand Loïc, Wilkens Lynne R, Bis Joshua C, Leonard Hampton, Shen Botong, Lange Leslie A, Giri Ayush, Dikilitas Ozan, Kullo Iftikhar J, Stanaway Ian B, Jarvik Gail P, Gordon Adam S, Hebbring Scott, Namjou Bahram, Kaufman Kenneth M, Ito Kaoru, Ishigaki Kazuyoshi, Kamatani Yoichiro, Verma Shefali S, Ritchie Marylyn D, Kember Rachel L, Baras Aris, Lotta Luca A, Kathiresan Sekar, Hauser Elizabeth R, Miller Donald R, Lee Jennifer S, Saleheen Danish, Reaven Peter D, Cho Kelly, Gaziano J Michael, Natarajan Pradeep, Huffman Jennifer E, Voight Benjamin F, Rader Daniel J, Chang Kyong-Mi, Lynch Julie A, Damrauer Scott M, Wilson Peter W F, Tang Hua, Sun Yan V, Tsao Philip S, O'Donnell Christopher J, Assimes Themistocles L
Abstract excerpt
We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including nine on the X chromosome,...
Read the complete abstract on PubMed