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Article

MEF2 intervened LPS-induced acute lung injury by binding to KLF2 promoter and modulating macrophage phenotype.

International immunopharmacology - 1 Jul 2022

Sun Qinying, Xia Yang, Qin Hao, Zhang Wei, Wang Jun, Ning Yunye, Dong Yuchao

Abstract excerpt

Transcription factor myocyte enhancer factor 2 (MEF2) exerts anti-inflammatory activities in endothelial cells, yet its role in acute lung injury (ALI) remains unclear. Homeostasis dysfunction in macrophage polarization is essential for the pathogenesis of ALI. Krüppel-like factor 2 (KLF2) and microRNA-33 (miR-33), important regulators in macrophage polarization, have been predicted as the downstream and upstream...

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Identifiers

PMID: 35729843
DOI: 10.1016/j.intimp.2022.108873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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