Transcription factors STAT6 and KLF4 implement macrophage polarization via the dual catalytic powers of MCPIP.

Abstract excerpt

Macrophage polarization plays a critical role in tissue homeostasis, disease pathogenesis, and inflammation and its resolution. IL-4-induced macrophage polarization involves induction of STAT6 and Krüppel-like factor 4 (KLF4), which induce each other and promote M2 polarization. However, how these transcription factors implement M2 polarization is not understood. We report that in murine macrophages MCP-1-induced...

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• CCAAT-Enhancer-Binding Protein-beta
• Endoplasmic Reticulum Stress
• Kruppel-Like Factor 4
• Kruppel-Like Transcription Factors