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Article

Krüppel-like factor 4 regulates macrophage polarization

13 Jun 2011

Abstract excerpt

Current paradigms suggest that two macrophage subsets, termed M1 and M2, are involved in inflammation and host defense. While the distinct functions of M1 and M2 macrophages have been intensively studied - the former are considered proinflammatory and the latter antiinflammatory - the determinants of their speciation are incompletely understood. Here we report our studies that identify Krüppel-like factor 4...

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PMID: 21670502
DOI: 10.1172/jci45444

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