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Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

Neurology - 28 Jul 2026

Morrill Valerie N, Pike James Russell, Hu Jiaqi, Fornage Myriam, Surapaneni Aditya, Walker Keenan A, Knopman David S, Mosley Thomas H, Coresh Josef, Schneider Andrea Lauren Christman, Smith Jason R, Gottesman Rebecca F

Abstract excerpt

BACKGROUND AND OBJECTIVES: Genetics represent a nonmodifiable risk factor for Alzheimer disease (AD), with 60%-80% heritability. Midlife hypertension is a modifiable risk factor for both dementia and death. Our primary objective was to determine how genetic risk for AD modifies the association between hypertension and dementia. METHODS: The Atherosclerosis Risk in Communities Study is an ongoing community-based...

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PMID: 42385118
DOI: 10.1212/WNL.0000000000218280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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