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Article

Depressive symptoms as a risk factor or prodrome of dementia: multi-state cognitive transitions modified by age and polygenic risk.

The journal of prevention of Alzheimer's disease - 1 Jun 2026

Ren Ziyang, Zhang Ruyi, Guo Shuai, Zhao Yihao, Liu Jufen, Zheng Xiaoying

Abstract excerpt

BACKGROUND: Whether depressive symptoms signal a risk factor or a prodromal symptom of dementia, and how this depends on age, genetic susceptibility, and cognitive stages, remains controversial. OBJECTIVES: To examine the association between depressive symptoms and incident dementia and cognitive transitions, and to test effect modification by age and AD genetic susceptibility (APOE and AD polygenic risk score...

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Identifiers

PMID: 42140010
DOI: 10.1016/j.tjpad.2026.100577
PMCID: PMC13199885

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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