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Article

Contribution and clinical relevance of germline variation to the cancer transcriptome.

BMC cancer - 20 Jun 2022

Pereira Bernard, Labrot Emma, Durand Eric, Korn Joshua M, Kauffmann Audrey, Campbell Catarina D

Abstract excerpt

BACKGROUND: Somatic alterations in the cancer genome, some of which are associated with changes in gene expression, have been characterized in multiple studies across diverse cancer types. However, less is known about germline variants that influence tumor biology by shaping the cancer transcriptome. METHODS: We performed expression quantitative trait loci (eQTL) analyses using multi-dimensional data from The...

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Identifiers

PMID: 35725412
DOI: 10.1186/s12885-022-09757-0
PMCID: PMC9208227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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